In an article on Cherokee beliefs concerning death, John Witthoft shares some inconclusive information on shamanic applications of various herbaceous plants and fungi to achieve visions. http://www.bigorrin.org/archive84.htm
Another curious statement appears in Time Before History, The Archaeology of North Carolina, by Trawick Ward and Stephen Davis. An odd discovery was made at excavated sites in two separate locations: Coweeta Creek in Macon County and Warren Wilson in Buncombe. At each of these sites, archaeologists uncovered the remains of a large number of toads. According to the authors, "the toads may have been used for hallucinogenic or medicinal purposes."
Several species of toads are psychoactive, but I have no idea which ones inhabit these mountains.
I have no idea how you would identify such toads.
Maybe you look for toads with telltale tie-dye markings.
Maybe you look for toads that are jamming out to Phish.
I don’t know.
Assuming you crossed paths with such a toad, it is possible to obtain the psychoactive ingredient from the toad’s venom glands. Stroking the toad under its chin stimulates a defensive response and release of hallucinogenic venom, which can be collected and dried. The toad takes about a month to refill its venom glands, but harvesting of venom in this manner can be accomplished without serious harm to the toad.
I have no idea what harm might befall a person who ingests the toad venom.
And it’s not something I intend to discover from personal experience.
But I pass along this information in the belief that everyone should know how to milk a toad.